Isopropylmagnesium Chloride Lithium Chloride Complex Powder CAS 745038-86-2

Products Description

What is Isopropylmagnesium chloride lithium chloride complex Powder CAS 745038-86-2 ?

Isopropylmagnesium Chloride Lithium Chloride Complex (CAS 745038-86-2), also known as chloro(1-methylethyl)magnesium lithium chloride, is an organomagnesium-lithium bimetallic reagent with a molecular formula of C3H7Cl2LiMg and a molecular weight of 145.24 g/mol. Commercially available as 1.0M–1.3M tetrahydrofuran (THF) solutions, it appears as a colorless to pale yellow transparent liquid, while the pure compound forms white crystalline solids.
The reagent exhibits a density of 1.05 g/mL (25°C, THF solution) and a flash point of -17°C, classifying it as highly flammable. It dissolves readily in aprotic solvents like THF and diethyl ether but reacts violently with water, producing isopropane gas, magnesium hydroxide, lithium chloride, and exothermic heat.

Basic Info

Isopropylmagnesium chloride lithium chloride complex Powder CAS 745038-86-2

Uses

As a Grignard reagent derivative, it is pivotal in organic synthesis:
Carbonyl Addition: Forms tertiary/secondary alcohols by reacting with aldehydes (e.g., benzaldehyde → 1-phenyl-2-propanol), ketones (e.g., acetone → 2-methyl-2-propanol), and esters.
Cross-Coupling Reactions: Participates in palladium-catalyzed Negishi coupling and nickel-catalyzed Suzuki-Miyaura coupling to introduce isopropyl groups into aryl/vinyl halides.
Heterocycle Construction: Used in synthesizing nitrogen-containing heterocycles for pharmaceutical intermediates (e.g., antimalarial agents).
Catalyst Precursors: Serves as a precursor for magnesium-lithium-based catalysts in polymerizations or organometallic materials.

Safety Information

Hazards:
H225 (highly flammable liquid and vapor), H260 (releases flammable gas in contact with water), H314 (causes severe skin burns and eye damage).
Risk statement: R11 (flammable), R14/15 (violent reaction with water), R34 (corrosive).
Safe operation:
Operate in a fume hood and wear protective equipment (gloves, goggles).
Absorb with inert adsorbent in case of leakage and avoid water treatment.
Storage conditions: Store in a sealed container at -20°C, away from ignition, oxidants and moisture.

Company Profile

Gneebio is an enterprise specialising in the research, development, production and sales of phytochemicals and fine chemicals.Our factory was established in 2016 and is located in Henan Province, covering an area of 3,600 square metres. We have a professional, well-equipped and high-quality R&D team with more than 10 years of R&D experience. Our reagent products are widely exported to many countries including the United States, Russia, Canada, Australia, Europe, etc., and we provide fast shipping services to our customers. We hope to establish long-term and mutually beneficial cooperation with more friends in the future and provide the best products and services for our customers.

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