CAS 29682-15-3 | 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

The compound corresponding to CAS 29682-15-3 is 5-bromopyridine-2-carboxylic acid methyl ester, a pyridine organic compound containing bromine atoms and ester groups. Its molecular formula is C₇H₆BrNO₂, molecular weight is 216.03 g/mol, it is a white crystalline solid at room temperature, melting point is 101–103°C, boiling point is about 290.9°C, and density is 1.579 g/cm³. The compound is slightly soluble in water and easily soluble in organic solvents such as methanol and ether.

Uses:

5-bromopyridine-2-carboxylic acid methyl ester is a synthetic precursor of heterocyclic compounds containing pyridine rings and is widely used to construct biologically active drug molecules. The bromine atom at position 5 and the methyl carboxylate group at position 2 in its structure give it high reactivity, and different substituents can be introduced through reactions such as Suzuki coupling, aminolysis, and hydrolysis, and it is used to synthesize antibacterial agents, antiviral drugs, and nervous system drugs.

Method of Preparation:
5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER is usually prepared by the following steps:
React 5-bromopyridine with anhydrous acetic acid to form 5-bromopyridine-2-acetic acid at low temperature.
React 5-bromopyridine-2-vinic acid with methanol to obtain methyl 5-bromopyridine-2-carboxylate.

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