Organometallic Reagents 1-Propynylmagnesium Bromide Solution CAS 16466-97-0

Products Description

What is Organometallic Reagents 1-Propynylmagnesium bromide solution CAS 16466-97-0 ?

1-Propynylmagnesium bromide (CAS 16466-97-0) is an organomagnesium compound with a molecular formula of C3H3BrMg and a molecular weight of 143.26 g/mol. It typically exists as a tetrahydrofuran (THF) solution at room temperature. Common aliases include bromo(prop-1-yn-1-yl)magnesium and 1-propynylmagnesium bromide, making it an important alkynyl Grignard reagent in organic synthesis.
1-Propynylmagnesium bromide has a density of 0.941 g/mL (25°C, THF solution), a boiling point of 65–67°C, and a flash point of -1°C. It is soluble in aprotic solvents such as THF and diethyl ether.

Basic Info

Organometallic Reagents 1-Propynylmagnesium bromide solution CAS 16466-97-0

Uses

As an alkynyl Grignard reagent, 1-Propynylmagnesium bromide primarily introduces alkynyl functional groups through reactions including carbonyl addition (reacting with aldehydes, ketones, and esters to form alkynol compounds like 1-cyclohexyl-2-propyn-1-ol), metal-catalyzed coupling (coupling with alkyl/aryl halides under palladium/nickel catalysis to construct carbon-carbon bonds for synthesizing complex olefins or aromatic derivatives such as mifepristone intermediates), and cyclization (reacting with conjugated olefins to generate hydroxy enynes, which undergo gold-catalyzed cyclization to form tetralin compounds).

Safety Information

Hazards: Highly flammable and corrosive, must be handled under inert gas protection.
Storage: Usually stored in a sealed container in 0.4–0.5 M THF solution, refrigerated (2–8°C).

Company Profile

Gneebio is an enterprise specialising in the research, development, production and sales of phytochemicals and fine chemicals.Our factory was established in 2016 and is located in Henan Province, covering an area of 3,600 square metres. We have a professional, well-equipped and high-quality R&D team with more than 10 years of R&D experience. Our reagent products are widely exported to many countries including the United States, Russia, Canada, Australia, Europe, etc., and we provide fast shipping services to our customers. We hope to establish long-term and mutually beneficial cooperation with more friends in the future and provide the best products and services for our customers.

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