99% Purity Methyl Magnesium Chloride Solution CAS 676-58-4

Products Description

What is 99% purity Methyl magnesium chloride Solution CAS 676-58-4 ?

Methylmagnesium Chloride is an organomagnesium compound with a CAS number of 676-58-4, a molecular formula of CH₃ClMg, and a molecular weight of 74.79 g/mol. Its common form is a tetrahydrofuran (THF) solution, with a concentration of usually 1.5M, 2.0M, 2.5M or 3.0M, and an appearance of a colorless to pale yellow transparent liquid.

Methyl magnesium chloride has a density of 1.013–1.04 g/mL (25°C) and forms an azeotrope with THF at 66°C. It exhibits a flash point of -17°C, making it highly flammable. Methylmagnesium Chloride reacts violently with water to produce methane gas, magnesium hydroxide, and significant heat, necessitating strict anhydrous conditions. It dissolves readily in aprotic solvents like THF and diethyl ether but is insoluble in protic solvents (alcohols, water).

Basic Info

99% purity Methyl magnesium chloride Solution CAS 676-58-4

Uses

As a prototypical alkyl Grignard reagent, it plays a key role in three major reaction types:
Carbonyl Addition: Forms alcohols by reacting with aldehydes (e.g., benzaldehyde → 1-phenyl ethanol), ketones (e.g., acetone → tert-butyl alcohol), and esters.
Cross-Coupling Reactions: Participates in Negishi coupling with aryl/vinyl halides (palladium catalysis) to introduce methyl groups in pharmaceutical intermediates like ciprofloxacin.
Heterocycle Synthesis: Used in synthesizing nitrogen-containing heterocycles (e.g., by reacting with nitriles to form ketones).

Safety Information

Classified as Danger under GHS, it poses risks including flammability (H225), water reactivity (H260), corrosivity (H314), and suspected carcinogenicity (H351). Handling requires inert gas protection and anhydrous techniques. Store at -20°C or under refrigeration to prevent decomposition, and avoid prolonged exposure to air/moisture.

Company Profile

Gneebio is an enterprise specialising in the research, development, production and sales of phytochemicals and fine chemicals.Our factory was established in 2016 and is located in Henan Province, covering an area of 3,600 square metres. We have a professional, well-equipped and high-quality R&D team with more than 10 years of R&D experience. Our reagent products are widely exported to many countries including the United States, Russia, Canada, Australia, Europe, etc., and we provide fast shipping services to our customers. We hope to establish long-term and mutually beneficial cooperation with more friends in the future and provide the best products and services for our customers.

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