CAS:18162-48-6 | T-Butyldimethylchlorosilane

Products Description

The substance corresponding to CAS No. 18162-48-6 is T-Butyldimethylchlorosilane. Its molecular formula isC6H15ClSi, molecular weight is about 150.72, appearance is white solid or white crystalline particles, melting point is about 86-89℃, boiling point is about 125℃, density is 0.87g/ml at 20℃, soluble in most organic solvents such as THF, dichloromethane, DMF, etc., but insoluble in water.
In addition, tert-Butyldimethylchlorosilane is sensitive to moisture and reacts rapidly in the presence of water. As a silanization agent, it can react with hydroxyl, ketone, ester, amide, etc. under mild conditions to generate corresponding silyl ethers and enol silyl ethers.

Basic Info

Uses

• Protective groups in organic synthesis: T-Butyldimethylchlorosilane is one of the most widely used important protective groups in organic synthesis. It is often used to protect functional groups such as alcohol hydroxyl, phenolic hydroxyl, amine, and amide to avoid unnecessary reactions of these functional groups in subsequent reactions.
• Pharmaceutical intermediates: It is used as an auxiliary raw material for the synthesis of prostaglandins, certain antibiotics, and lipid-lowering drugs such as lovastatin and simvastatin.
• Derivatization reagent: It can be used as a derivatization reagent for analysis and preparation. For example, in gas chromatography/mass spectrometry analysis, compounds containing active hydrogen can be converted into corresponding silyl ether derivatives to improve the sensitivity and selectivity of the analysis.
• Other applications: T-Butyldimethylchlorosilane can be used as an anion capture reagent to capture anions generated by some organic lithium reagents, etc., to form stable silyl ether compounds, which are further used in organic synthesis reactions.

Safety Information

• T-Butyldimethylchlorosilane is irritating, avoid contact with skin and eyes.
• Good laboratory operation practices should be followed when using it, and personal protective equipment such as safety gloves and goggles should be worn.
• It should be sealed during storage to avoid contact with flammable materials and oxidants to prevent fire and explosion.

Company Profile

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