CAS:4038-14-6丨3,4-Dimethoxybenzophenone

3,4-Dimethoxybenzophenone (CAS 4038-14-6) is an important fine chemical intermediate. Its molecular structure consists of two benzene rings connected by a carbonyl group, and the 3rd and 4th positions of one of the benzene rings are substituted by methoxy groups. The molecular formula is C₁₅H₁₄O₃, and the molecular weight is 242.27 g/mol.
3,4-Dimethoxybenzophenone appears as a white to light yellow crystalline powder, with a melting point of 102-104°C and a boiling point of 335°C. It is slightly soluble in water but easily soluble in organic solvents such as ethanol and acetone.

Uses:

3,4-Dimethoxybenzophenone is a key intermediate for the synthesis of antihypertensive drug methyldopa and anti-Parkinson's disease drug levodopa methyl ester hydrochloride. The synergistic effect of its methoxy and carbonyl groups can inhibit central α-adrenergic receptors and improve dopaminergic neurotransmission function.
In materials science, this compound can be used as a photoinitiator in UV-curing coatings. After absorbing ultraviolet light, it produces active free radicals to initiate polymerization reactions. It can also be used to synthesize nematic liquid crystal materials to improve the response speed and contrast of display devices.

Method of Preparation:

3,4-Dimethoxybenzophenone can be prepared by a condensation reaction of benzophenone with methanol and formic acid in the presence of an acid catalyst. The reaction is typically carried out at a certain temperature and pressure. The process involves mixing benzophenone, methanol, and formic acid, followed by the addition of the acid catalyst. After the reaction, purification steps are required to obtain the pure product.

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