What is anisole/methoxybenzene (CAS 100-66-3) used for?

Sep 09, 2025 Leave a message

Anisole(CAS 100-66-3), chemically known as phenyl methyl ether or methoxybenzene, is an organic compound with a distinctive aroma. It is widely found in nature, especially in spice plants such as fennel and star anise. Due to its unique fragrance and stability, anisole is commonly used in perfumes, fragrances, and as a flavoring agent in food.

 

Anisole Formula and Structure

  • Molecular formula: C₇H₈O
  • Molecular weight: 108.14 g/mol
  • CAS No.: 100-66-3
  • Synonyms: Anisole, Methoxybenzene
  • Anisole CAS 100-66-3 structure:

    Anisole CAS 100-66-3 structure


Anisole Properties

  • Appearance: Colorless transparent liquid with a phenolic or anise-like odor
  • Melting point: –37 °C
  • Boiling point: 153.6–155 °C (at atmospheric pressure)
  • Density: 0.995–0.996 g/cm³ (25 °C)
  • Refractive index: 1.516 (20 °C)
  • Flash point: 44.5–51.7 °C (closed cup), classified as a flammable liquid

 

Anisole Solubility and Polarity

  • Water solubility: 1.6–1.71 g/L (20 °C)
  • Solubility: Easily soluble in ethanol, ether, and other organic solvents
  • Relative polarity: 0.198 (low-polarity solvent)

 

Anisole Uses

 

Anisole Uses

Anisole application in fragrance industry
It enhances floral, spicy, and sweet notes, improving scent longevity and depth, making it essential for high-quality perfumes and personal care products.

Anisole used in pharmaceuticals
In pharmaceuticals, anisole serves as a precursor for active pharmaceutical ingredients (APIs).

Anisole use in pesticide intermediates
Anisole is used in pesticides, herbicides, and fungicides as a stabilizer and reaction intermediate, contributing to controlled release and product stability.

Methoxybenzene for dye intermediates
Anisole's solvency and stability make it a useful solvent for coatings, adhesives, and chemical processes, providing uniformity and consistency in formulations.

 

What is Toluene Solvent? Key Industrial Uses

 

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