6-Methylnicotinate, CAS No.: 5470-70-2, is a colorless or light yellow liquid at room temperature and pressure. 6-Methylnicotinate is a pyridine derivative with a certain alkalinity. It can be used as an organic synthesis and biochemical intermediate, and can be applied to the preparation of bioactive molecules, pesticide molecules and fungicides.
Medicine
6-Methylnicotinate is used as a d-amino acid oxidase and d-aspartate oxidase inhibitor to treat central nervous system diseases.
6-Methylnicotinate is used as a raw material for the synthesis of a variety of bioactive molecules in the medical field, including d-amino acid oxidase (DAO) and d-aspartate oxidase (DAO) inhibitors. These inhibitors have potential application value in the treatment of central nervous system diseases.
d-Amino acid oxidase is an enzyme present in the human intestine and blood, which can catalyze the oxidative deamination reaction of d-amino acids. DAO inhibitors can inhibit the activity of this enzyme, thereby reducing the absorption and utilization of d-amino acids by the intestine and reducing the concentration of d-amino acids in the blood. This is of great significance for the treatment of some central nervous system diseases caused by d-amino acid metabolic disorders.
Similarly, d-aspartate oxidase is also an important biological enzyme that participates in the synthesis of purine bases. DAO inhibitors can inhibit the activity of this enzyme, thereby blocking the synthesis of purine bases, and have potential application value in the treatment of some central nervous system diseases caused by purine base metabolic disorders.
6-Methylnicotinate is a pyridine derivative and an intermediate in organic synthesis. It can be used to synthesize etoricoxib API.
Etoricoxib is a non-steroidal anti-inflammatory drug mainly used to treat mild to moderate pain, inflammation and fever. In the process of synthesizing etoricoxib, 6-methylnicotinate plays an important role as an important intermediate.
