Sodium triacetoxyborohydride is a new catalyst for reductive amination developed in recent years. It is easily soluble in benzene and tetrahydrofuran. It is a mild selective borohydride reagent. It reacts with water and is soluble in acetonitrile and 1,2-dichloroethane. Because of its excellent universality and selectivity, mild reaction conditions, good catalytic reduction performance, and easy separation and purification, the catalyst itself and by-products are non-toxic and do not pollute the environment, it has become the preferred catalyst for reductive amination.
Sodium triacetoxyborohydride is mainly used for various reduction reactions such as reductive amination and carbonyl reduction. It can be used for amination reduction of ketones and aldehydes, reductive amination/lactamization of carbonyl complexes and amines, and reductive amination of aromatic aldehydes.
Safety information:
1. Sodium triacetoxyborohydride is irritating to the skin and eyes. Care should be taken to avoid contact during operation. Wear protective gloves and goggles if necessary.
2. During storage and handling, avoid contact with water vapor in the air because it is sensitive to water and will decompose.
The preparation method of sodium triacetoxyborohydride is as follows:
Suspend an appropriate amount of sodium borohydride in benzene, add an appropriate amount of glacial acetic acid, and then slowly drop an appropriate amount of acetic anhydride. After the reaction is completed, filter to obtain a solid, wash it with tetrahydrofuran and dry it.
