CAS 287944-16-5 | 3,6-Dihydro-2H-pyran-4-boronic Acid Pinacol Ester

3,6-Dihydro-2H-pyran-4-boronic Acid Pinacol Ester is an organoboron reagent, mainly used in Suzuki-Miyaura coupling reaction, which can introduce structural fragments containing pyran rings in the reaction. Its molecular formula is C₁₁H₁₉BO₃, and its molecular weight is about 210.08 g/mol.

3,6-Dihydro-2H-pyran-4-boronic Acid Pinacol Ester is usually a colorless to pale yellow liquid, insoluble in water, and easily soluble in organic solvents such as tetrahydrofuran and dichloromethane. It is relatively stable to air and moisture and is suitable for storage under normal conditions.

Uses:

3,6-Dihydro-2H-pyran-4-boronic Acid Pinacol Ester is mainly used in the synthesis of pharmaceutical intermediates, such as the construction of antibacterial and antiviral drugs containing pyran rings; it can also be used as a key building block for the total synthesis of natural products, or participate in the preparation of fluorescent probes and functional materials.

Preparation:
- The preparation of 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester is generally obtained by the base-catalyzed reaction of pyran with boronic acid pinacol. The specific preparation method can be chosen according to the actual needs, and common preparation methods include using sodium borate and pinacol to react under alkaline conditions.

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