CAS:50358-63-9 | 6-Amino-5-bromoquinoxaline

6-Amino-5-bromoquinoxaline is a white to pale yellow solid with a faint peculiar odor. It is stable at room temperature but decomposes when heated. It is insoluble in water but soluble in some organic solvents.

Uses:
6-Amino-5-bromoquinoxaline is mainly used as an intermediate compound that plays an important role in the synthesis of other compounds. It can be used in the synthesis of pesticides, dyes and other organic compounds.

6-Amino-5-bromoquinoxaline is an inhibitor of serine proteases that has been shown to be effective in cell culture and in wild-type mice. It inhibits the enzyme by binding to the catalytic site, blocking the formation of a covalent bond between polypeptide chain and amino acid substrate. It has also been shown to have an inhibitory effect on fibrinogen and polyclonal antibodies and can be used as a buffer for other proteases. In addition, this compound also inhibits caproic acid production from fatty acids via an unknown mechanism. It is not active against synthetic substrates or monoclonal antibodies.

Method of Preparation:
It is generally prepared by a two-step reaction. 5-Bromoquinoxaline is obtained by reacting quinoxaline with ammonium bromide or barium bromide. Then 5-bromoquinoxaline is reacted with ammonia to obtain the final product 6-amino-5-bromoquinoxaline.

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