CAS:313-12-2 | 2-Amino-3-(trifluoromethyl)benzoic Acid

2-Amino-3-(trifluoromethyl)benzoic Acid (CAS 313-12-2) is a fluorine-containing organic compound with molecular formula C₈H₆F₃NO₂ (molecular weight 205.14). It appears as a white crystalline solid with a benzoic acid-like odor.
This compound exhibits a melting point of 157–160°C, boiling point of 296.9°C, flash point of 133.3°C, density of 1.489 g/cm³, and refractive index of 1.533. The molecular structure contains amino and trifluoromethyl-substituted benzoic acid groups, endowing it with both polarity and lipophilicity. It is slightly soluble in water and highly soluble in organic solvents such as ethanol and ether.

As a fluorinated aromatic acid, its trifluoromethyl group enhances lipophilicity and metabolic stability of compounds. It is widely used in the synthesis of fluorine-containing drugs and pesticide active ingredients. For instance, derivatization of amino and carboxylic acid groups enables the synthesis of nitrogen-containing heterocycles or amide derivatives, which are applied in the development of antibacterial and anti-inflammatory agents.

Preparation method aspect: There are multiple ways to prepare 2-Amino-3-(trifluoromethyl)benzoic Acid. A common preparation method is to react hydroquinone with 1,1,1-trifluoroethyl ether, and obtain the target product after appropriate treatment and transformation reactions.

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