CAS:17852-52-7 | 4-Hydrazinylbenzenesulfonamide Hydrochloride

The compound corresponding to CAS 17852-52-7 is 4-Hydrazinylbenzenesulfonamide Hydrochloride, with a molecular formula of C₆H₁₀ClN₃O₂S and a molecular weight of 223.68.
4-Hydrazinylbenzenesulfonamide Hydrochloride is a white to light yellow crystalline powder, hygroscopic, with a melting point of about 211°C (decomposition), slightly soluble in water, easily soluble in polar organic solvents such as ethanol and acetone, and has a high solubility in DMSO.

Uses:

Pharmaceutical field: 4-Hydrazinylbenzenesulfonamide Hydrochloride is used as a key intermediate in the synthesis of the non-steroidal anti-inflammatory drug Celecoxib, which exerts anti-inflammatory and analgesic effects by inhibiting cyclooxygenase-2 (COX-2) and is widely used in the treatment of osteoarthritis, rheumatoid arthritis and acute pain.
Pesticide field: As an intermediate of insecticides or herbicides, its hydrazine structure can be combined with other active groups to enhance the biological activity and durability of the pesticide.

Method of Preparation:

4-Hydrazinylbenzenesulfonamide hydrochloride can be prepared in several ways. Commonly used methods include the nitration reaction method and the condensation reaction method. In the nitration reaction method, aniline and carbamate undergo nitration reaction followed by reduction to obtain 4-hydrazinylbenzenesulfonamide hydrochloride. In the condensation reaction method, aniline and amide compounds are condensed and then sulfurized to obtain the product.

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