CAS:147118-36-3 | 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol

Products Description

The substance with CAS number 147118-36-3, 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-yl-methanol, is an intermediate of rosuvastatin calcium. Its molecular formula is C₁₆H₂₀FN₃O₃S, with a molecular weight of 353.4117, a LogP of 3.37500, and a PSA of 91.77000.
In terms of physical and chemical properties, the rosuvastatin calcium intermediate typically appears as a white or off-white powder with a melting point of 138–143°C.

Basic Info

Safety Information

Irritation: This substance may have a certain irritation effect on the skin, eyes and respiratory tract. Contact may cause redness, itching, pain on the skin, stinging, tearing, swelling of the eyes, as well as respiratory discomfort, coughing and other symptoms.
Flammability: It has a certain degree of flammability and may burn under certain conditions. It should avoid contact with open flames, high temperatures, strong oxidants, etc.

Uses

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-yl-methanol is an important intermediate in the synthesis of rosuvastatin calcium. It is used to produce rosuvastatin calcium. Rosuvastatin calcium, a selective 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, can reduce the synthesis and storage of cholesterol in liver cells. As a result, it helps lower the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the blood, playing an important role in the prevention and treatment of cardiovascular diseases.

Company Profile

Gneechem, located in Henan Province, China, is part of the GNEE Group, with 22 years of experience in foreign trade, specializing in providing high-quality chemical raw materials and professional trading services to customers around the world. We supply basic chemical raw materials, fine chemicals and specialty chemicals for a wide range of industries.We are ISO9001 certified and have been recognized by a number of authoritative qualifications at home and abroad, making us a trusted partner of our customers.

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