CAS: 149809-43-8 Posaconazole Impurity 53

(5R-cis)-Toluene-4-sulfonic Acid 5-(2,4-Difluorophenyl)-5-[1,2,4]triazol-1-ylmethyltetrahydrofuran-3-ylmethyl Ester is also known as TMSOTf, which is a commonly used reagent in organic synthesis. It is a white to off-white powder and is easily soluble in acetonitrile and dimethyl sulfoxide. It is soluble in methanol. It is almost insoluble in water.
Posaconazole Impurity 53 is irritating and corrosive to the skin, eyes and respiratory tract. When using it, wear appropriate protective gloves, safety glasses and protective clothing to avoid contact.

1. As a strong acid catalyst: Posaconazole Impurity 53 can be used as an acid catalyst in a variety of reactions to promote etherification, esterification, phosphorylation and other reactions of ketones.
2. As a dehydrating agent: Posaconazole Impurity 53 can be used as a dehydrating agent under non-aqueous conditions, and is often used in the dehydration reaction of compounds such as ethers and alcohols.
3. As a sulfonic acid protecting group for aromatic compounds: Posaconazole Impurity 53 can react with aromatic amines to generate products containing sulfonates, thereby playing the role of protecting amine groups.

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