CAS:42330-59-6 | 2-Chloro-3-pyridinylmethanol

2-Chloro-3-pyridinylmethanol CAS No. 42330-59-6 is an important organic synthesis intermediate with a molecular formula of C₆H₆ClNO and a molecular weight of about 143.57 g/mol. Common aliases of this compound include 2-Chloro-3-pyridinyl)methanol, etc. It is a light yellow needle-shaped solid with a purity of 97%~98%.
The physical and chemical properties of 2-Chloro-3-pyridinylmethanol are as follows: density of about 1.3 g/cm³, boiling point of 276.7°C at normal pressure, boiling point of 112°C at 0.03 kPa pressure; melting point of 54~55°C, flash point of 121.2°C. This substance is slightly soluble in water and easily soluble in organic solvents such as methanol.

Uses:

As a pharmaceutical intermediate, 2-chloro-3-pyridinemethanol is mainly used to synthesize antiviral drugs (such as conazole antifungal drugs) and other pharmaceutical compounds containing pyridine structures. The chlorine atoms and hydroxyl groups in its molecules provide active sites for subsequent chemical reactions, and the target molecules can be constructed through reactions such as nucleophilic substitution and coupling.

Method of Preparation:
- A common synthetic method is to obtain 2-Chloro-3-pyridinylmethanol by reacting 2-pyridinecarboxaldehyde with hydrogen chloride. The reaction requires the use of ferrous chloride (FeCl2) as a catalyst and is carried out at room temperature.

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