CAS 1516887-33-4 | (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic Acid

Products Description

(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic Acid has a white powder appearance, a density of 1.142 g/cm³, a boiling point of 573.1 °C, and a pKa value of 4.76.
(3alpha,5beta)-6-Eethylidene-3-hydroxy-7-oxocholan-24-oic Acid uses 7-oxo-lithocholic acid as a raw material, and is protected at the 3-hydroxyl group or the 3-hydroxyl group and the 24-carboxyl group, or is directly unprotected, and further reacts with acetaldehyde through an aldol condensation reaction to obtain an intermediate, and then the product can be obtained through acid treatment and other steps.

Basic Info

Uses

The application of (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic Acid mainly includes its use as an intermediate of obeticholic acid in the pharmaceutical field. (E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic Acid is a byproduct in the synthesis of obeticholic acid and may be useful in the treatment of liver diseases.

Company Profile

Gneechem, located in Henan Province, China, is part of the GNEE Group, with 22 years of experience in foreign trade, specializing in providing high-quality chemical raw materials and professional trading services to customers around the world. We supply basic chemical raw materials, fine chemicals and specialty chemicals for a wide range of industries.We are ISO9001 certified and have been recognized by a number of authoritative qualifications at home and abroad, making us a trusted partner of our customers.

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