CAS:2304-96-3 | N-Benzyloxycarbonyl-L-asparagine

N-Benzyloxycarbonyl-L-asparagine, abbreviated as Cbz-Asn or Z-Asn-OH, is the N-benzyloxycarbonyl protected form of L-asparagine. This compound is commonly used in organic synthesis and peptide synthesis to protect the amino part of amino acids and prevent undesirable side reactions during the synthesis process. It is a derivative of L-asparagine, whose amino part is protected by benzyloxycarbonyl to form a protected form of amino acid. The structure of this compound contains an amide group and an N-benzyloxycarbonyl group.

1. It is often used to protect the amino part of L-asparagine in solid-phase and liquid-phase peptide synthesis to prevent adverse reactions or degradation during the synthesis process.
2. The protecting group can be effectively removed under specific conditions, such as catalytic hydrogenation or acidic conditions.
3. It is used as an intermediate in organic synthesis to synthesize more complex bioactive molecules and natural products. Its protecting group keeps the amino acid stable under complex reaction conditions.
4. In medicinal chemistry, it is used to design and synthesize new drug candidates and study anticancer, antibacterial and other bioactive compounds.

1. It has good stability under normal conditions, but it is still necessary to pay attention to its toxicity.
2. When operating, wear appropriate personal protective equipment to avoid direct contact with skin and eyes.
3. When storing and handling, avoid fire and high temperature.
4. It should be stored in a dry, well-ventilated place, away from oxidants and strong acids and alkalis.

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