2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety known for the synthesis of diverse biological molecules. Many pharmaceutical companies across the globe aim to synthesise low-molecular weight molecules for use as pharmacophores against various biological targets.
Aminopyridine is a white or clear colored crystalline solid. It is soluble in water and alcohol. It is toxic by ingestion and by inhalation of the dust. It is used to make pharmaceuticals and dyes.
Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.
2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety known for the synthesis of diverse biological molecules. Many pharmaceutical companies across the globe aim to synthesise low-molecular weight molecules for use as pharmacophores against various biological targets. 2-Aminopyridine can serve as a perfect locomotive in the synthesis and pulling of such molecules towards respective pharmacological goals. The major advantage of this moiety is its simple design, which can be used to produce single products with minimum side reactions. Moreover, the exact weight of synthesised compounds is low, which enables facile identification of toxicity-causing metabolites in drug discovery programmes. This manuscript is a quick review of such pharmacophores derived from 2-aminopyridine.
Simple or complex structures with grafted moiety 2-aminopyridine, have been shown to be effective as antitumoral, anti-Alzheimer, antidiabetic, antimicrobial, antiviral, analgesic, anti-inflammatory, antiparasitic, antimalarial, antihistaminic, anticonvulsant, Renininhibitors, n-NOS-inhibitors, CXCR1/2 inhibitors, JNK1 inhibitors, PKC inhibitors, Syk-inhibitors and also with cardiac activity. This review presents the most representative literature which highlights the role of 2-aminopyridine as pharmacophore in various compounds with medicinal properties. The study highlights the central role of 2-aminopyridine moiety in the pharmacological properties of the synthesized molecule.