5-Cyanophthalide is a commonly used intermediate in organic synthesis and pharmaceutical chemistry. It is mostly used in the synthesis of organic functional material molecules and drug molecules, and is mainly used in basic chemical research and pharmaceutical chemical production.
Chemical properties:
Physical state: White or light yellow crystals at room temperature and pressure.
Solubility: Hardly soluble in water, but soluble in common organic solvents such as acetone, chloroform, etc.
Structural features: Contains a highly reactive cyano unit and a lactone structure.
Stability: Stable at room temperature, but may change when heated.
Melting point: Approximately 202-204ºC.
Molecular weight: 159.14.
CAS registration number: 82104-74-3.
EINECS registration number: 279-900-2.
Application:
Organic synthesis intermediate: 5-cyanophthalide is often used in the synthesis of organic functional material molecules and drug molecules as an important intermediate.
Medicinal chemistry: 5-Cyanophthalide can be used as a pharmaceutical chemical intermediate and can be used in the synthesis of anticancer drug molecules. For example, 5-cyanophthalide is the key synthetic intermediate of the drug molecule Citalopram. Citalopram is a selective serotonin reuptake inhibitor. This drug molecule can selectively inhibit the 5-HT transporter, block the reuptake of 5-HT by the presynaptic membrane, prolong and increase the effect of 5-HT, and thus produce an antidepressant effect..
Chemical reaction: Due to the active groups in its structure, it can undergo a variety of chemical reactions, such as electrophilic substitution, reduction, addition, etc.