Chinese name: 2,4-Diamino-6- chloropyrimidine
English name: 2,4-Diamino-6- chloropyrimidine
Molecular formula: C4H5N4Cl
CAS NO: 156-83-2
Use: Intermediate of chlorpyrifos
Appearance: White to off-white crystalline powder
Physical properties
Appearance: usually white to light yellow crystalline powder.
Melting point: 209-211℃.
Chemical properties
The chlorine atom in the 2,4-diamino-6-chloropyrimidine molecule has a certain reactivity and can undergo a variety of chemical reactions such as substitution reactions, which enables it to participate as an intermediate in the synthesis of various organic compounds such as chloramine.
Preparation method
Usually, ethyl cyanoacetate can be used as the starting material, reacted with guanidine to generate 2,4-diaminopyrimidine-6-carboxylic acid ethyl ester, and then chlorinated to obtain 2,4-diamino-6-chloropyrimidine. The specific reaction conditions and processes will vary depending on the manufacturer and actual needs.
Application
2,4-Diamino-6-chloropyrimidine is an important chemical raw material with a wide range of applications. It is mostly used in the synthesis and structural modification of drug molecules, such as the synthesis of the antihypertensive drug chlorpyrifos. Chlorpyrifos is an antihypertensive drug that dilates arterioles and lowers blood pressure. It is suitable for the treatment of refractory hypertension, severe hypertension and renal hypertension. In addition, it also plays an important role in the pharmaceutical, dye and plant protection agent industries.