CAS 139301-27-2 | 4-Trifluoromethoxyphenylboronic Acid

4-Trifluoromethoxyphenylboronic Acid (CAS 139301-27-2) is a fluorinated aromatic boronic acid compound with a molecular formula of C₇H₆BF₃O₃, a molecular weight of 205.93 g/mol, and a structural formula of CF₃OC₆H₄B(OH)₂. The para-position of the benzene ring is connected to the trifluoromethoxy group and the boronic acid group.
4-Trifluoromethoxyphenylboronic Acid is a white to light yellow crystalline powder with a melting point of 123–127°C. It is slightly soluble in water and easily soluble in organic solvents such as methanol and tetrahydrofuran. It is sensitive to humidity and needs to be sealed to prevent hydrolysis.

Uses:

Pharmaceutical R&D: 4-Trifluoromethoxyphenylboronic Acid is a key intermediate in the Suzuki-Miyaura coupling reaction and is used to synthesize anti-tumor drugs (such as lactate dehydrogenase inhibitors), anti-tuberculosis drugs (such as PA-824 analogs) and neurological disease treatment drugs (such as PAI-1 inhibitors).
Material Science: Participate in the preparation of fluorinated optoelectronic materials and liquid crystal monomers, and use the electron-withdrawing property of trifluoromethoxy to optimize material properties.

Method of Preparation:
4-Trifluoromethoxyphenylboronic acid is generally prepared by the following reaction:
The reaction between distilled benzo-p-trifluoromethoxyphenol and boric acid is carried out at a certain temperature to form 4-trifluoromethoxyphenylboronic acid.

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