CAS:149105-19-1 | 2-Carboxyphenylboronic Acid

The corresponding compound of CAS 149105-19-1 is 2-Carboxyphenylboronic Acid, with a molecular formula of C₇H₇BO₄ and a molecular weight of 165.94 g/mol. It is an important organic synthesis intermediate with wide applications in medicine, materials science and analytical chemistry.
2-Carboxyphenylboronic Acid is a white to light yellow crystalline powder at room temperature with a melting point range of 138–141°C (decomposition). The presence of carboxyl and boronic acid groups in its molecules makes it hydrophilic to a certain extent. It is slightly soluble in water and easily soluble in polar organic solvents such as methanol, ethanol, N,N-dimethylformamide (DMF), but insoluble in non-polar solvents such as n-hexane and ether.

Uses:

Pharmaceutical intermediates
Drug synthesis: 2-Carboxyphenylboronic Acid is a key reagent in the Suzuki coupling reaction and is used to construct carboxyl-containing drug molecules, such as the intermediate synthesis of the non-peptide thrombopoietin receptor agonist Eltrombopag.
Nano drug delivery: In biomimetic nano drug systems, 2-carboxyphenylboronic acid can enhance drug targeting by specifically binding to glycoproteins. For example, the Yantai University team used it to construct a ferroptosis inhibitor delivery system to treat acute kidney injury.

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