Products Description
Verubecestat is a β-amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor. Structurally, it is a small molecule compound. Its structure is designed based on the understanding of the active site of the BACE1 enzyme. Through rational drug design, the drug molecules can specifically bind to the active site of the BACE1 enzyme, thereby exerting the effect of inhibiting the enzyme activity. The research and development process of Verubecestat (MK-8931) has provided valuable experience and references for the subsequent development of drugs for Alzheimer's disease.
Basic Info
| CAS | 1286770-55-5 |
| Chemical formula | C17H17F2N5O3S |
| Molecular weight | 409.41 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Melting point | 160-162oC |
| Solubility | DMSO (slightly soluble), methanol (slightly soluble) |
| Acidity coefficient | 9.92±0.70(Predicted) |
| Storage conditions | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Appearance | solid |
| Color | White |
Uses
In vitro study:
Verubecestat (MK-8931) effectively reduces Aβ40 in cells with a Ki value of 7.8 nM and an IC50 of 13 nM.
In vivo study:
A single oral administration of Verubecestat (MK-8931) to rats and cynomolgus monkeys can significantly reduce cerebrospinal fluid (CSF) and cortical Aβ40. The half-life of MK-8931 in the body is 20 hours, which is suitable for the frequency of administration once a day.
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Company Profile
Have more than 10 years of experience.
Arranging orders and shipments in time according to customers' requirements, providing complete customs clearance documents according to export policies of different countries.
With 1000 square meters of office and 3000 square meters of warehouse to ensure your efficiency and warehousing.
Wide range of products: more than 500 kinds of products with competitive price, and we can take full responsibility if there is any quality problem with our products.
Provide price trends to ensure that our customers keep abreast of market information.
FAQ
Can we visit your company/factory before placing an order?
It is our honor. We sincerely welcome you to visit Gnee Chem Company and we guarantee you will have a pleasant trip to China!
How do you guarantee the quality of your products?
We conduct physical and chemical tests on existing products and develop new products. The quality of our products is guaranteed by Sichuan Institute of Metallurgy and Guangzhou Institute of Metals, and our long-term cooperation with them saves our customers a lot of testing time.
How to get the samples?
Please send us your address, we are honored to provide samples for you.
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