CAS NO.830-81-9 1-Acetoxynaphthalene

1-Acetoxynaphthalene is an esterification product formed by the reaction of naphthol with acetic acid.
Properties:
- APPEARANCE: 1-Acetoxynaphthalene is a colorless or slightly yellow oily liquid.
- Solubility: it is soluble in organic solvents such as ethanol, ether and aromatic hydrocarbons, insoluble in water.

Uses:
- Acetic acid-1-naphthyl ester is used as a raw material and solvent for organic synthesis.

1-Acetoxynaphthalene is a cell-permeable esterase substrate that has been demonstrated to be effective in the treatment of lymphocytic leukemia, lung cancer, and Alzheimer's disease. It has been demonstrated that 1-naphthyl acetate inhibits tumor growth in mice by inhibiting cytochrome P450 enzymes. Furthermore, 1-naphthyl acetate has been shown to effectively inhibit protein kinase activity in human cells. Consequently, it may have potential as a therapeutic agent for leukemia and Alzheimer's disease.

Preparation:
1-Acetoxynaphthalene can be prepared by an esterification reaction between acetic acid and naphthol. A common method of preparation is to obtain it by reacting acetic acid with naphthol by heating in the presence of an acid catalyst.

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