24589-78-4 | N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Properties:
- Appearance:N-Methyl-N-(trimethylsilyl)trifluoroacetamide is a colorless liquid.
- Stability: N-Methyl-N-(trimethylsilyl)trifluoroacetamide is stable to water and air, but hydrolysis reaction may occur under strong alkali conditions.

Among the derivatization reagents used for gas chromatography, the derivatization reaction of the silylation reagent and the sample compound is carried out by substituting the active hydrogen of the hydroxyl group, carboxyl group, mercapto group, amino group and imino group with silyl group.

Uses:
- As a reagent: N-Methyl-N-(trimethylsilyl)trifluoroacetamide is commonly used as a reagent and activator in organic synthesis.
- As a photosensitive polymer material: it may be used in the preparation of photosensitive polymers for use in photolithography and microelectronic manufacturing.
Description：

N-Methyl-N-(trimethylsilyl)trifluoroacetamide is an organic solvent used for the extraction of hydroxylated fatty acids from human serum. MSTFA is a derivative of trifluoroacetic acid and is used for the extraction of hydroxylated fatty acids. The derivatization reaction mechanism involves a nucleophilic substitution reaction between the amine group on MSTFA and the hydroxyl group on the fatty acid. This reaction occurs in aqueous solution and is greatly influenced by pH. To remove matrix effects, such as ionic strength and pH, it is necessary to use dispersive solid phase extraction for sample preparation.

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