Pharmaceutical Intermediate (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one CAS 76855-69-1

Products Description

The substance corresponding to CAS 76855 - 69 - 1 is (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one, also known as 4-acetoxyazetidin-2-one. Its molecular formula is C₁₃H₂₅NO₄Si and its molecular weight is 287.427.

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one presents as a white to pale yellow crystalline powder. It has a density of 1.0±0.1 g/cm³, a boiling point of 358.3±27.0 °C at 760 mmHg, a melting point of 107 - 109 °C, a flash point of 170.5±23.7 °C, a vapor pressure of 0.0±0.8 mmHg at 25 °C, and a refractive index of 1.464.

Basic Info

Safety Information

Dangerous goods symbol: Xi (irritant), N (harmful to the environment)
Hazard category code: R36 (eye irritation), R43 (may cause skin allergy), R51/53 (toxic to aquatic organisms, may have long-term adverse effects on the aquatic environment)
Safety instructions: S24 (avoid skin contact), S26 (if accidentally contact with eyes, please rinse with plenty of water and seek medical advice), S37 (wear appropriate gloves), S61 (avoid release to the environment, refer to special instructions/safety data sheet)
Dangerous goods transport number: UN 3077

Uses

As an intermediate of penem antibiotics: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one is a key intermediate for the synthesis of penem antibiotics. Penem antibiotics have the advantages of broad antibacterial spectrum, strong antibacterial activity, and stability against β-lactamase. They are widely used in the treatment of various serious infectious diseases in clinical treatment. Based on it, a variety of penem drugs such as meropenem, imipenem, and panipenem can be synthesized.

Company Profile

Gnee Chem is an enterprise specialising in the research, development, production and sales of phytochemicals and fine chemicals.Our factory was established in 2016 and is located in Henan Province, covering an area of 3,600 square metres. We have a professional, well-equipped and high-quality R&D team with more than 10 years of R&D experience. Our products are widely exported to many countries, such as the United States, Russia, Canada, Australia, Europe, etc., and we provide customers with fast shipping services. We hope to establish long-term and mutually beneficial cooperation with more friends in the future, and provide the best products and services for our customers.

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