CAS:1435934-00-1丨LDN 193189 Hydrochloride

The corresponding compound of CAS 1435934-00-1 is LDN 193189 Hydrochloride, the chemical name is 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride, the molecular formula is C₂₅H₂₂₄Cl₂N₆, and the molecular weight is 479.40.
LDN 193189 Hydrochloride is a selective bone morphogenetic protein (BMP) type I receptor inhibitor. It inhibits the BMP signaling pathway by targeting ALK2 and ALK3 kinases, and has important application value in scientific research.

Uses:

Research on BMP signaling pathway
As a tool compound LDN 193189 Hydrochloride can specifically block BMP-induced Smad1/5/8 phosphorylation and analyze the role of BMP signal in embryonic development, bone metabolism and stem cell differentiation. For example, in the ** progressive ossification fibrous dysplasia (FOP)** model, it can significantly reduce ectopic ossification and functional impairment.
Stem cell biology
Combined with other inhibitors (such as SB431542), it can induce the differentiation of human pluripotent stem cells (hPSCs) into nerve cells, including motor neurons, nociceptive neurons, etc., providing tools for the construction of neurological disease models.

Preparation:
The method of preparation of LDN 193189 Hydrochloride involves a number of steps such as synthesis of the compound, crystallization and preparation of the hydrochloride form. The method of preparing LDN-193189 2HCL can be referenced through literature.

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