Products Description
ABT199INT is a high-quality compound that can be used as a reagent or intermediate. It is a complex compound with the CAS No. 1228780-72-0 that is useful in the production of fine, research, and specialty chemicals. ABT199INT is a versatile building block used in reactions to produce specialized products.
Basic Info
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ITEMS |
SPECIFICATION |
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| cas | 1228780-72-0 | ||
| Chemical formula | C19H27ClN2 | ||
| Molecular weight: | 318.8841 | ||
| Density | 1.072±0.06 g/cm3 (predicted value) | ||
| Boiling point | 421.2±45.0°C (predicted value) | ||
| Acidity factor | 9.21±0.10 (predicted) | ||
USES & EFFECTIVENESS
ABT199INT was not sensitive to Bcl-XL, McL-1, or Bcl-W. Abt-199 stopped the growth of FL5.12-Bcl-2 and RS4;11 cells. It was less active against FL5.12-Bcl-XL cells. Abt-199 caused RS4;11 cells to die quickly. Western blotting showed that ABT-199 worked better on cell lines with more bcl-2. Abt-199 also induced CLL apoptosis with an average EC50 of 3.0nM. Abt-199 (100mg/kg) treated RS4; it stopped tumor growth. Chemicalbook Abt-199 stopped tumors from growing in DoHH2 and Granta 519 grafts.
ABT199INT is effective in fighting cancer and has fewer side effects than existing drugs. Unlike common anticancer drugs, the drug abT-199 works by attacking an important protein called Bcl-2, one of the first members of the bcl-2 family of proteins that regulate cell death and have been linked to a variety of cancers, as well as a number of mental disorders and autoimmune diseases. In cancer, it is thought to act as an inhibitory factor that helps cancer cells resist cancer treatment drugs.Abt-199 is a novel anticancer drug that inhibits the growth of bcl-2 without affecting Bcl-XL, a protein essential for platelet formation.
Company Profile
TIANJIN GNEE BIOTECH CO., LTD. has decades of experience in manufacturing and marketing high-quality chemicals. Our product range includes organic chemicals, biochemicals, pharmaceutical intermediates, and more.
Our skilled workforce in research and development ensures that we can provide our customers with quality testing, production control, and after-sales service. We are a one-stop service provider for R&D and production solutions for our global customer base.
FAQ
Please advise on the procedure for confirming product quality before placing orders.
Some products are available for free sample purposes, with the shipping cost or courier arrangements to be borne by the customer. Please forward your product specifications and requests to us, and we will manufacture the products according to your specifications.
Do you provide product reports?
Affirmative. We will provide you with a product analysis report prior to shipping.
Are discounts available?
Please note that discounts vary depending on the quantity ordered.
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