CAS:4312-44-1 | 6-Hydroxyquinoline-4-carboxylic Acid

6-Hydroxyquinoline-4-carboxylic acid is an organic carboxylic acid compound containing a quinoline skeleton, with a molecular formula of C₁₀H₇NO₃, a molecular weight of 189.17 g/mol, and a CAS number of 4312-44-1.
6-Hydroxyquinoline-4-carboxylic acid is a grayish white to pale yellow crystalline solid with a melting point of 320°C. It is slightly soluble in water and soluble in organic solvents such as alcohol, chloroform and benzene.

Uses:

Pharmaceutical intermediates:
6-Hydroxyquinoline-4-carboxylic acid is used to synthesize anti-fibrosis drugs and tumor diagnostic agents (such as imaging agents based on FAP-α targets). Its quinoline structure can bind to biological targets, and the carboxylic acid group can participate in esterification or amidation reactions to introduce functional fragments.
Organic synthesis:
As a nitrogen-containing heterocyclic carboxylic acid, it can be used to prepare quinoline derivatives (such as methyl esters and ethyl esters), which are used in the fields of pesticides or optoelectronic materials.

Method of Preparation:

The preparation method of 6-Hydroxyquinoline-4-carboxylic acid can be obtained by subjecting quinoline to a hydroxymethylation reaction and then subjecting the product to a carboxylation reaction.

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