CAS 253678-65-8 | Fos-Choline-11, Sol-Grade

Fos-Choline-11, Sol-Grade, also known as 1,2-heneicosanoyl-sn-glycero-3-phosphocholine, or DPC for short, is a commonly used cationic surfactant of phosphorylcholine. It is composed of a dodecyl chain and a phosphorylcholine head group and is a very important detergent in the study of membrane proteins and nuclear magnetic resonance structure analysis.

Properties：

1. Fos-Choline-11, Sol-Grade is widely used to dissolve and stabilize membrane proteins.
2. Due to its similarity to cell membrane phospholipids, it can effectively dissolve cell membranes while maintaining the biological activity and structural integrity of membrane proteins.
3. This makes it important in the study of membrane protein structural biology, especially in nuclear magnetic resonance and X-ray crystallography analysis.

Uses：

1. Fos-Choline-11, Sol-Grade can be used as an effective detergent with excellent cleaning performance and low critical micelle concentration, so it can form a stable micelle structure, which helps to maintain the native state of proteins.
2. Due to its good solubility, low toxicity and similarity with membrane components, it is often used as a detergent for membrane proteins and peptides in NMR studies.
3. It has a small denaturing effect on proteins, which makes it effective in maintaining the activity and function of these molecules during the extraction, separation and purification of biomacromolecules.

1. Dispose of waste in accordance with local environmental regulations and avoid discharge into natural water bodies.
2. Wear appropriate personal protective equipment such as gloves and goggles during handling.
3. Follow the operating instructions provided by the manufacturer and the recommendations in the safety data sheet to ensure safe use.

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