CAS 139504-50-0 | N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine

Products Description

Mertansine is a derivative of Maytansine and a natural alkaloid. Maytansine was originally extracted from the genus Maytansine and its relatives in the Celastraceae family and has a strong ability to inhibit tumor cell proliferation. However, due to the strong toxic side effects of Maytansine itself, medicinal chemists modified it to obtain Mertansine
N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine is a solid at room temperature and pressure, and can be dissolved in ethyl acetate, dichloromethane and alcohol solvents, but has poor solubility in ether solvents and water. It is unstable in solution.

Basic Info

Uses

Mertansine is mainly used in antibody-drug conjugates (ADCs), which specifically target tumor cells by connecting to monoclonal antibodies. ADCs are composed of three parts: monoclonal antibodies that target specific antigens, drugs with cytotoxins, and linkers that connect antibodies and toxins. Mertansine, as a cytotoxin component, prevents tumor cell division by destroying mechanisms such as tubulin, thereby killing cells.

Company Profile

Gneechem, located in Henan Province, China, is part of the GNEE Group, with 22 years of experience in foreign trade, specializing in providing high-quality chemical raw materials and professional trading services to customers around the world. We supply basic chemical raw materials, fine chemicals and specialty chemicals for a wide range of industries.We are ISO9001 certified and have been recognized by a number of authoritative qualifications at home and abroad, making us a trusted partner of our customers.

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