Acetonitrile (acn) in The Pharmaceutical Industry

What is Acetonitrile?

Acetonitrileis a chemical compound that has the formula CH3CN. This colorless substance is the simplest organic nitrile. Hydrogen cyanide, HCN, is a simpler nitrile, but the cyanide anion (CN–) is not classed as organic.

Acetonitrile is manufactured mainly as a by-product of acrylonitrile and is used as a polar aprotic solvent in organic synthesis and in the cleansing of butadiene.

Acetonitrile (acn) Chemical Properties

It is a nitrile (hydrogen cyanide) with a methyl group instead of hydrogen. Additionally, it is a polar compound, meaning its atoms can attract electrons to themselves. Furthermore, the nitrogen atom has a greater electronegative charge than the carbon atom.

Physical properties of Acetonitrile

• It has the appearance of a colorless, transparent liquid with a pleasant aroma.
• It's a low-density base with a density of 0.783 g/cm3.
• The melting point is -46 to -44 degrees Celsius, while the boiling temperature is 81.3 to 82.1°Celsius.
• In water, it is miscible.

Acetonitrile (AcN) in Pharmaceutical Industry

Acetonitrile (AcN) plays multiple critical roles in the pharmaceutical industry, primarily serving as a solvent, reaction medium, and synthetic intermediate.

As a Solvent and Reaction Medium: Acetonitrile (acn) is widely used in drug synthesis reactions due to its excellent solubility and miscibility with solvents like water and alcohols, providing an ideal reaction environment for various organic reactions. It is particularly suitable for the recrystallization process of steroid drugs, aiding in the purification of active pharmaceutical ingredients.

Chromatographic Analysis: Due to its low UV absorption and chemical stability, acetonitrile is the preferred mobile phase for HPLC and mass spectrometry, particularly suited for separating and detecting complex drug components.

As a Pharmaceutical Synthesis Intermediate: Acetonitrile (AcN) serves as a direct raw material for synthesizing numerous critical drugs and their active components. Drugs synthesized using it include:

• Vitamin B1 (Thiamine)
• Metronidazole (an antibacterial and antiprotozoal drug)
• Ethambutol (used to treat tuberculosis)
• ‌Aminopterin (a diuretic)
• ‌Adenine (a nucleoside compound serving as a fundamental structural unit for many drugs)

‌As an extraction solvent: In pharmaceutical purification processes, acetonitrile (ACN) facilitates the extraction and separation of target drug molecules from reaction mixtures, enhancing product purity and yield.

Why Choose Gneebio for Acetonitrile (cas 75 05 8) Supply?

Gneebio is a professional manufacturer and distributor of high-purity Acetonitrile (cas 75 05 8), offering factory-direct supply and large-volume delivery.

Advantages for Industrial Buyers

• Bulk Production & Stable Supply: Reliable monthly capacity to avoid production delays
• Strict Quality Control: COA, MSDS, TDS, and optional third-party testing
• Flexible Packaging Options: 200L drums, 1000L IBC, ISO tanks
• Global Export Experience: Efficient shipping and compliance with international chemical regulations

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